Expression of P190 and P210 BCR/ABL1 in normal human CD34(+) cells induces similar gene expression profiles and results in a STAT5-dependent expansion of the erythroid lineage The P190 and P210 BCR/A

NIAID Data Ecosystem60

Tissue and differentiation stage specific expression of CALM/AF10 is required for leukemogenesis

白血病发病机制

血液肿瘤分子病理学

The translocation t(10,11)(p13;q14) resulting in the formation of the CALM/AF10 fusion gene is involved in various hematological malignancies including acute myeloid leukemia, T-cell acute lymphoblast

NIAID Data Ecosystem60

Molecular and transcriptional characterization of chromosome 17p loss in chronic lymphocytic leukemia

肿瘤基因组学

血液肿瘤分子病理学

Distinct genetic abnormalities such as TP53 deletion at 17p13.1, have been identified as having an adverse prognostic relevance in B-cell chronic lymphocytic leukemia (B-CLL). Conventional cytogenetic

NIAID Data Ecosystem70

RNA-seq in different hematopoietic stem and progenitor cell subpopulations of patients with chronic and progressed polycythemia vera and controls

血液肿瘤分子病理学

单细胞转录组学

Hematopoietic stem/multipotent progenitor cells (HSC/MPPs, referred to as HSCs) can differentiate into functionally divergent cell lineages including common myeloid progenitors (CMPs), megakaryocyte-e

NIAID Data Ecosystem60

Clonal hematopoiesis is driven by aberrant activation of TCL1A

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