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Decrease in Rnase HII and accumulation of lncRNAs/DNA hybrids: a causal implication in psoriasis?
Long functional non-coding RNAs (lncRNAs) have been in the limelight in aging research because short telomeres are associated with higher levels of TERRA (Telomeric Repeat containing RNA). The genomic
NIAID Data Ecosystem80
Development of gene expression signatures for psoriasis
To further explore the gene expression signatures in psoriatic, we have employed whole genome microarray expression profiling as a discovery platform to identify the potential genes that play a role i
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Additional file 7 of Chromatin accessibility and transcriptome integrative analysis revealed AP-1-mediated genes potentially modulate histopathology features in psoriasis
Additional file 7: Table S2. Methylation levels for loci located within the accessible peaks.
Figshare2024-02-29 更新20
JNK1 Signaling Downstream of the EGFR Pathway Contributes to Imiquimod-induced Skin Inflammation (RNA-seq)
c-Jun N-terminal protein kinase 1 (JNK1) is involved in multiple biological processes but its implication in inflammatory skin diseases is still poorly defined. Herein, we studied the role of JNK1 in
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Bulk RNA sequencing of skin biopsies from psoriasis patients treated with roflumilast or placebo
This sub-study investigated the cellular and molecular effects of oral roflumilast treatment on psoriatic skin. Patients with moderate-to-severe psoriasis were allocated 1:1 to monotherapy with oral r
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