Association of replication origins with CGIs and TSSs, as a function of replication timing category.

Number and percentage of origins in each timing category (from early to late). Origins classified as CGI (or TSS) correspond to origins that strictly overlap with a CGI (or TSS). The positions of CGIs and TSSs were taken from the UCSC Genome Browser annotation. Expected (Exp.) percentage and significance of association ( for significant enrichment, with ) are computed with random genomic segments sampled from mappable regions (see Materials and Methods).