Universities of St Andrews, Dundee and Glasgow

The Dundee/St Andrews/Glasgow BAG continues to move forward with fundamental research into a range biological processes. Early stage drug discovery remains a key research interest where structural data can inform on target assessment and support compound screening and medicinal chemistry projects. Projects across the BAG include:- characterization of enzymes producing natural products or involved in biocatalysis; antibiotic discovery; enzyme kinetics and regulation; the role of O-GlcNAc modification in cytosolic proteins; RNA structure and DNA junctions; ubiquitin signalling and transfer; bacterial type 6 secretion system; protein degradation and protein-protein interactions; pseudokinase regulation of the innate immune response. Synchrotron beamtime provides us with increased throughput, resolution, and quality of data to drive our research forward, optimising and clarifying diffraction data collected in-house, and complementing a range of other biophysical research techniques.