Summary of 15 tagging SNPs chosen for the EAGLE study.

aThe minor allele frequency was estimated based on the control samples in the EAGLE study.
bThe per-allele OR and the one degree of freedom Wald test for the association between lung cancer and the SNP based on the logistic regression model adjusted for smoking intensity, age, and gender. The SNP genotype was coded as the copy number of the minor alleles.
cLoadings of individual SNPs on the first and second principal components based on the principal component analysis conducted on the selected subjects from the EAGLE study used in the real-data application. The highlighted values in the PC2 column are the ones that dominate the definition of the 2nd principal component.