Global studies of Genome-Wide DNA Methylation Patterns on porcine longissimus dorsi muscle

In order to discover the systematic association between DNA methylation and meat quality, we analyzed the whole-genome DNA methylation patterns in longissimus dorsi muscle by using methylated DNA immunoprecipitation sequencing (MeDIP-seq) in the two breed pigs . Our results showed that a total of 1425 differentially methylated genes (DMGs) were identified (447 hyper-methylated and 978 hypo-methylated) between YY and WH. Gene ontological functional analysis identified 346 terms and 139 genes that may be potential key regulators of pig meat quality. Overall design: Epigenetic modifications in two breed pigs