SC83288 thermostability responses (ITDR-CETSA)

This dataset contains the full results of the isothermal dose–response cellular thermal shift assay (ITDR-CETSA) performed on <i>Plasmodium falciparum</i>–infected erythrocytes treated with the antimalarial candidate SC83288. The data include all detected parasite and host proteins, quality-control information, curve-fitting metrics, thermal shift parameters, and processed dose–response data used to identify proteins showing significant SC83288-induced changes in thermal stability.The ITDR-CETSA experiment was performed on trophozoite-stage <i>P. falciparum</i> (25 ± 3 hpi) exposed to increasing concentrations of SC83288 (7.7 pM to 3.0 µM) for 1 h. Protein thermostability was assessed at four temperatures (37 °C control; 50 °C; 55 °C; 60 °C). Soluble protein fractions were analyzed by quantitative mass spectrometry.ReferenceSanchez <i>et al.</i>, <i>Inhibition of PfDNMT2 and PfATP6-mediated resistance to the antimalarial candidate SC83288 in</i> <i>Plasmodium falciparum</i>, in revision.<br>