Candida auris Clade V

Candida auris has emerged globally as a multidrug-resistant pathogen which causes outbreaks in health care facilities. Whole genome sequencing (WGS) analysis has identified four major clades, while WGS data from a single Iranian isolate suggested the existence of a potential fifth clade. Here, we confirm the existence of this fifth clade by WGS data of five Iranian isolates. These clade V isolates differed < 100 SNPs between each other, while they were separated from the other clades by > 200,000 single-nucleotide polymorphisms (SNPs). Two of these isolates were resistant to fluconazole and were found to harbor mutations in the TAC1b and ERG11 genes.