Association of genetic variants against lipid ratios in the Busselton Health Study.

Genome-Wide Association Study was performed on 82 Lipid Ratios using imputed genotype (13.8 million SNPs) data from the Busselton Health Study (n = 4,492). The top 10 SNPs to associate with each lipid ratio were included in the table. 1Lipid nomenclature is read as follows: letters denote the head group; () brackets denote the sum composition of the lipid measured including total number of carbons and double bonds; [] denote the position of the acyl chain; n3 and n6 denote omega-3 and omega-6 poly-unsaturated fatty acid species; 2SNP: single-nucleotide polymorphism; 3EAF: effect allele frequency; 4GWAS was performed on lipid ratios and individual lipid species to identify the significance of each SNP; 5SE: standard error; 6p-gain was calculated by dividing the lowest p-value among the lipid species used in the ratio by the p-value of the lipid ratio. The p-gain was deemed significant if it exceeded 10 × the number of significant SNPs identified for each ratio. Significant p-gains are depicted in red.
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