Botswana Combination Prevention Project (BCPP) - Public Release Data

The Botswana Combination Prevention Project (BCPP) was a research project conducted by the Botswana Ministry of Health (MOH), Harvard School of Public Health/Botswana Harvard AIDS Institute Partnership (BHP), and the U.S. Centers for Disease Control and Prevention (CDC). BCPP was a community randomized trial that examined the impact of prevention interventions on HIV incidence in 15 intervention and 15 control communities. The interventions included extensive HIV testing, linkage to care, and universal treatment services. To reduce HIV incidence in the intervention communities, the UNAIDS 90-90-90 goals were used: 90% of HIV-positive persons know their status; 90% of persons who know status are to be on ART; 90% of persons on ART are to be virally suppressed. The BCPP study is composed of 2 interlocking protocols: Evaluation Protocol and Intervention Protocol. The Evaluation Protocol of the BCPP evaluated the primary endpoint (HIV incidence), as well as some key related secondary endpoints. This protocol focused on the Baseline Household Survey; the HIV Incidence Cohort; and an End of Study Survey. The Intervention Protocol of the BCPP implemented the combination prevention (CP) intervention package in CPCs and measures the uptake of these interventions (expanded HIV testing and counselling, strengthened male circumcision, and expanded HIV Care and Treatment).

博茨瓦纳综合预防项目（BCPP）是一项由博茨瓦纳卫生部（MOH）、哈佛大学公共卫生学院/博茨瓦纳哈佛艾滋病研究所合作伙伴（BHP）以及美国疾病控制与预防中心（CDC）共同开展的研究项目。BCPP是一项社区随机对照试验，旨在探究预防干预措施对15个干预社区和15个对照社区HIV发病率的影响。干预措施包括广泛的HIV检测、链接护理和普遍的治疗服务。为降低干预社区的HIV发病率，项目采用了联合国艾滋病规划署的90-90-90目标：90%的HIV阳性患者了解自己的状况；90%了解自身状况的患者将接受抗逆转录病毒治疗（ART）；90%接受ART治疗的患者将实现病毒抑制。BCPP研究由两个相互关联的方案组成：评估方案和干预方案。BCPP的评估方案评估了主要终点（HIV发病率）以及一些关键的相关次要终点。本方案重点关注基线家庭调查；HIV发病率队列；以及研究结束时的调查。BCPP的干预方案在社区预防中心（CPCs）实施综合预防（CP）干预方案，并测量这些干预措施（扩大HIV检测和咨询、加强男性结扎以及扩大HIV护理和治疗）的采纳率。