Survival

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Oral
tongue squamous cell carcinomas (OTSCC) are a homogenous group of
head and neck tumors characterized with aggressive behavior among
younger age group of patients.
In this report, we have analysed genetic, transcriptomic, and
epigenetic variants across genomes of 50 oral tongue primary tumors
along with the human papilloma virus infection to find significant
association with disease free survival. Our
data identified somatic mutations in the genes NOTCH2,
TP53
and LOH in 11p,
and DNA methylation in SLC38A8
to be significantly associated with better disease free survival in
HPV positive patients (P
= 0.000175),
but not in HPV negative patients (P
= 0.974).
We validated the latter using patients without HPV infection from
TCGA (P
= 0.679, N = 15 for TCGA_OralTongue; P
= 0.262, N = 43
for all TCGA_HNSCC patients).