Stereoselective Synthesis of Constrained Oxacyclic Hydroxyethylene Isosteres of Aspartic Protease Inhibitors: Aldol and Mukaiyama Aldol Methodologies for Branched Tetrahydrofuran 2-Carboxylic Acids

The synthesis of diastereomeric 3-substituted-tetrahydrofuran 2-carboxylic acids in enantiopure
form was achieved relying on aldol condensations of N-substituted α-amino aldehydes with enolates
and enol silyl ethers of γ-butyrolactone. Catalytic YbFOD leads to a high yield of a syn/syn-α-amino alcohol isomer. This was used as a constrained THF subunit in the synthesis of a
peptidomimetic intended as an inhibitor of the enzyme BACE1, which is implicated in the cascade
of events leading to plaque formation in Alzheimer's disease.