Supporting data for "The role of the gut microbiome and bile acid metabolism in chronic liver diseases"

The file contains the supporting data for the thesis entitled "The role of the gut microbiome and bile acid metabolism in chronic liver diseases".  

Description of the dataset
We aim to identify potential new biomarkers for differentiation of MAFLD and chronic HBV infection under different disease courses by bile acid profiling and gut microbiota study.

Firstly, we addressed the role of human gut virome in fecal microbiota transplantation (FMT) and metabolic dysfunction-associated fatty liver disease (MAFLD) by investigating the metagenome dataset of a human gut microbiota-associated murine (HMA) model of MAFLD. To this end, gut virome data for the subjects in the HMA model was obtained, the dataset include the gut virome  data and a supplementary file.

Secondly, we aimed to identify the composition of the gut microbe and profile of ciculating bile acids in a chronic HBV patients. Moreover, we tried to disentangle the relationship between  the two chronic liver diseases in te perspective of gut microbiota and bile acid metabolism. Therefore, clinical measurements, bile acid profile, gut microbiome data were obtained.

本文件收录了题为《肠道微生物群和胆汁酸代谢在慢性肝病中的作用》的论文所支持的数据。该数据集旨在通过胆汁酸谱分析和肠道微生物群研究，识别在不同病程中区分非酒精性脂肪性肝病（MAFLD）和慢性乙型肝炎感染的新生物标志物。首先，我们通过研究与MAFLD相关的人类肠道微生物群小鼠（HMA）模型的宏基因组数据集，探讨了人类肠道病毒群在粪便微生物群移植（FMT）和代谢功能障碍相关脂肪性肝病（MAFLD）中的作用。为此，收集了HMA模型中受试者的肠道病毒群数据，数据集包括肠道病毒群数据和补充文件。其次，我们旨在识别慢性乙型肝炎患者肠道微生物组成和循环胆汁酸谱。此外，我们还试图从肠道微生物群和胆汁酸代谢的角度，揭示两种慢性肝病之间的关联。因此，收集了临床测量数据、胆汁酸谱和肠道微生物群数据。