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Cryo-EM structure of CAK in complex with inhibitor ICEC0574

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Protein Data Bank Japan2024-11-13 更新2026-05-23 收录
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Cryo-EM structure of CAK in complex with inhibitor ICEC0574 Descriptor: (3R,4S)-4-[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]pyrrolidin-3-ol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ... Authors: Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J. Deposit date: 2023-05-30 Release date: 2024-03-20 Last modified: 2024-11-13 Method: ELECTRON MICROSCOPY (2 Å) Cite: High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nat Commun, 15, 2024

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2023-05-30
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