SPATIOTEMPORAL EFFECT OF DIFFERENT ERADICATION THERAPIES FOR HELICOBACTER PYLORI INFECTION ON THE COMPOSITION AND FUNCTION OF THE WHOLE GASTROINTESTINAL MICROBIOTA PART 3

Active eradication of Helicobacter pylori may lead to risks such as microbiota imbalance and antibiotic resistance. Most previous studies have focused on the short term effects of triple and quadruple regimens on gut bacteria. ln contrast, only a few studies have targeted the evaluation of dual therapy and tailored therapy, as well as the effects on other microorgannisms, such as fungi, viruses, and archaea. This prospective cohort study aimed to systematically evaluate the short term effects of the classical bismuth quadruple therapy, dual therapy, and tailored therapy on gut microecology, covering a multilevel analysis of bacteria, fungi, viruses, archaea, antibiotic resistance genes, and functional pathwavs .After eradication therapy, the results indicated a significant imbalance in the gut microecology, antibiotic resistance genes, and functional pathwavs and could not be fully recovered in the short term.The disturbance caused by dual therapy was milder and recovered more quickly than bismuth quadruple therapy, followed by tailored therapy. This study established an important basis for optimizing Helicobacter pylori eradication strategies in the future.