Inhibition of phosphatidylinositide 3-kinase impairs the benzyl isothiocyanate-induced accumulation of autophagic molecules and Nrf2 in human colon cancer cells
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https://tandf.figshare.com/articles/dataset/Inhibition_of_phosphatidylinositide_3-kinase_impairs_the_benzyl_isothiocyanate-induced_accumulation_of_autophagic_molecules_and_Nrf2_in_human_colon_cancer_cells/5432737/1
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资源简介：
The regulating role of phosphatidylinositide 3-kinase (PI3K) in benzyl isothiocyanate (BITC)-induced Nrf2 activation, contributing to the inducible expression of cytoprotective genes, was investigated. BITC significantly enhanced the accumulation of Nrf2 as well as autophagic molecules in human colorectal cancer HCT-116 cells. Experiments using a PI3K-specific inhibitor suggested that PI3K plays the key role in the non-canonical Nrf2 activation by BITC.
提供机构：
Taylor & Francis
创建时间：
2017-09-22
