A Dominant mutation in Dnmt1 leads epigenetic changes (scRNAseq and snRNAseq)

We report the application of single cell and single nucleus rna-seq in the prefrontal cortex and retina from the Dnmt1 A560V mice Examination the epigenetic changes and gene expression changes due to Dnmt1 mutation我们报道了将单细胞RNA测序（single cell RNA-seq）与单细胞核RNA测序（single nucleus RNA-seq）应用于Dnmt1 A560V小鼠前额叶皮层与视网膜组织的研究，并借此检测了Dnmt1突变所引发的表观遗传变化与基因表达变化。