The transcriptomic profile of mice small intestine upon different duration of HFD feeding at both fasted and refed states

So far, the dynamic changes of small intestine upon different duration of the high-fat feeding at fasted and refed status and their underlying molecular mechanisms are not well investigated. To this end, we established the fasted and refed mouse models after feeding C57BL/6J mice with normal chow diet (NCD) or high fat diet (HFD) for different duration (12w, 30d, 10d and 3d), and explored the whole transcriptome sequencing of the mice upper jejunum.