CEBPA gene transcription is enhanced by RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, MYB, LEF1, and CEBPA

RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), MYB, and CEBPA itself all contribute to the level of transcription of CEBPA in hemopoietic progenitor cells and myeloid progenitor cells (inferred from mouse homologs). High levels of CEBPA appear to favor CEBPA:CEBPA homodimers and lead to granulopoiesis; low levels of CEBPA appear to favor CEBPA:AP-1 heterodimers and lead to monopoiesis. LEF1 also directly activates transcription of CEBPA (Skokowa et al. 2006, Skokowa et al. 2012), but appears to act at the transition of granulocyte-macrophage precursors to promyelocytes, a later stage of granulopoiesis. <br>The relative levels of SPI1 (PU.1) and CEBPA (SPI1 to CEBPA mRNA expression ratio) in granulocytic–macrophage progenitors have been suggested to regulate monocyte versus neutrophil cell-fate choice (Dahl et al. 2003).

RUNX1、SPI1（PU.1）、GATA2、TAL1（SCL）、MYB以及CEBPA本身均对造血祖细胞和髓祖细胞中CEBPA转录水平产生影响（据小鼠同源基因推断）。CEBPA高表达似乎有利于CEBPA:CEBPA同源二聚体的形成，进而促进粒细胞生成；而CEBPA低表达则倾向于形成CEBPA:AP-1异源二聚体，导致单核细胞生成。LEF1亦能直接激活CEBPA的转录（Skokowa等，2006；Skokowa等，2012），但其作用似乎发生在粒细胞-巨噬细胞祖细胞向原粒细胞转变的过程中，即粒细胞生成的后期阶段。《SPI1（PU.1）》与《CEBPA》在粒细胞-巨噬细胞祖细胞中的相对水平（SPI1与CEBPA mRNA表达比）已被提出可调控单核细胞与中性粒细胞命运选择（Dahl等，2003）。