Targeting nucleoporin 214 selectively eliminates leukemia stem cells

NIAID Data Ecosystem2026-05-02 收录

白血病靶向治疗

核孔蛋白功能研究

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https://www.omicsdi.org/dataset/pride/PXD054471 数据链接链接失效反馈

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LSCs from MLL-AF9-driven Nup214fl/fl and Nup214fl/fl,Tie2-Cre AML mice were sorted, followed by further proteomic assay.

创建时间：

2025-07-26

Genetic and chemical targeting of the ATPase complex TIP48 and 49 impairs acute myeloid leukemia

白血病靶向治疗

ATP（三磷酸腺苷）

The chromatin-associated AAA+ ATPases Tip48 and Tip49 are the core components of various complexes implicated in diverse nuclear events such as DNA repair and gene regulation. Although they are freque

NIAID Data Ecosystem60

Albumin binding domain fused to a mutant of the Erwinia asparaginase

蛋白质工程药物设计

白血病靶向治疗

Albumin binding domain fused to a mutant of the Erwinia asparaginase Descriptor: ASPARTIC ACID, L-asparaginase Authors: Lavie, A, Nguyen, H.A. Deposit date: 2022-03-04 Release date: 2022-08-31 Last mo

Protein Data Bank Japan2024-10-23 更新30

Genetic or pharmacological inactivation of CREBBP sensitizes B-cell Acute Lymphoblastic Leukemia to Ferroptotic Cell Death upon BCL2 Inhibition. Genetic or pharmacological inactivation of CREBBP sensitizes B-cell Acute Lymphoblastic Leukemia to Ferroptotic Cell Death upon BCL2 Inhibition

白血病靶向治疗

铁死亡机制

We performed a targeted drug screen in isogenic human cell lines, identifying a number of actionable small molecules that specifically target CREBBP-mutated B-ALL. The most potent was the BCL2 inhibit

NIAID Data Ecosystem20

Amplified EPOR/JAK2 genes define a unique subtype of acute erythroid leukemia

白血病分子分型

白血病靶向治疗

Acute erythroid leukemia (AEL) is a unique subtype of acute myeloid leukemia characterized by prominent erythroid proliferation, whose molecular basis is poorly understood. To elucidate the underlying

NIAID Data Ecosystem30

A potent and selective small-molecule degrader of ENL suppresses leukemia progression in vivo (ChIP-Seq)

白血病靶向治疗

蛋白降解靶向嵌合体

ENL, a stoichiometric component of the Super Elongation Complex (SEC) as well as the histone H3K79 methyltransferase DOT1L complex, is involved in the regulation of transcription elongation. Loss-of-f

NIAID Data Ecosystem20

Targeting nucleoporin 214 selectively eliminates leukemia stem cells

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