Rhodium-Catalyzed Diastereoselective [3 + 2] Cycloaddition of Carbonyl Ylide: An Access to the Core Ring System of Cordigol and Lophirone H

This paper describes a new synthetic strategy for the construction of tricyclic chromeno/quinolino furan frameworks via creation of two new rings and three contiguous stereogenic centers with high diastereoselectivity through a rhodium-catalyzed intramolecular carbonyl ylide cycloaddition reaction for the first time. This protocol allows the synthesis of the core ring system of natural products such as cordigol and lophirone H.