Difamilast treatment inhibits the expression of inflammatory mediators in bone marrow-derived basophils (BMBAs) stimulated by IL-3 + IL-33
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https://www.ncbi.nlm.nih.gov/sra/SRP441965
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资源简介：
In this study, we explored gene expression profiles of IL-3+IL-33-stimulated BMBAs treated with difamilast, a highly selective PDE4B inhibitor. We identified that difamilast-treated basophils showed downregulated expression of inflammaory mediators including Il4, Il6 and Il13. Overall design: Bone marrow-derived basophils were stimulated with IL-3+IL-33 or control PBS for 4hrs in the presence of difamilast or vehicle DMSO, and were subjected to bulk RNA-seq analysis.
创建时间：
2023-10-14
