I-Mutant results for selected nsSNPs in the TRIM22 protein.

# Del. Pred. = number of deleterious predictions; nsSNPs with 4 or more deleterious predictions are considered high-risk nsSNPs, while nsSNPs with less than 4 deleterious predictions are considered low-risk; DDG: free energy change value in Kcal/mol (>0 increase, 0.5 large increase, Figure S1); Sites with an additional ConSurf result in parentheses are located next to putative functional (9e) or structural (9b) residues; nsSNPs with the largest predicted stability decreases (DDG