Programmed death 1 receptor blockade and immune-related gene expression profiling in non-small cell lung carcinoma, head and neck squamous cell carcinoma and melanoma

RNA from tumor samples from 65 patients with melanoma, lung cancer, head and neck treated anti-PD1was analyzed on the nCounter system using the PanCancer 730-Immune Panel. Twenty-three immune-related genes or signatures were linked to response. The intra- and inter-biopsy variability of PD1, PDL1, CD8A and CD4 mRNA.