scRNA-seq analysis revealed the molecular characteristics of erythroid cells in spleen upon HAPC

High-altitude polycythemia (HAPC) is a most common chronic mountain sickness, characterized by excessive erythrocytosis caused primarily by persistent arterial hypoxia and ventilatory impairment. It has been a serious public health problem in high-altitude regions. Despite numerous studies on HAPC via genomics, transcriptomics or metabolome approaches, the pathogenesis of HAPC remains largely unclear. Here, we performed single-cell RNA sequencing to reveal the change of transcriptomics profiles of MNC in spleen of mice between HAPC subjects and healthy controls. Single-cell RNA sequencing for MNC in spleen of mice between HAPC models and healthy controls.