SPOP mutation reshapes chromatin landscape and transcriptional response to androgens [ATAC-seq]
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https://www.ncbi.nlm.nih.gov/sra/SRP249565
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To define the epigenomic response to AR activation, we employed the 3D organoid model of murine prostate tissue. Control and SPOP-mutant prostate organoids were stimulated with 10 nM dihydrotestosterone (DHT) or vehicle. Next, we performed the transcriptomic analysis (mRNA-seq) together with profiling of the accessibility landscape (ATAC-seq), transcription factor (AR, and FOXA1) binding and H3K4me2 modified nucleosomes. Overall design: Genome-wide profiling of accessibility in Control (normal) and SPOP-mutant mouse prostate organoids. Please note that each *bw file was generated from all replicates and is linked to the corresponding rep.1 sample records.
创建时间：
2021-09-12
