Contains supplementary materials and results, organized in Tables A-D and Figure A, and supplementary references.

Table A in S1 File. Clinical and pathological data of the cHL patients included in the survival analyses. Table B in S1 File. Antibodies used in the study. Table C in S1 File. Relationships between clinical characteristics and immunohistochemical variables. IHC protein expression was quantified using an automated scan, Chroma Vision Systems- ACIS III (DAKO, Glostrup, Denmark), analysing the whole area of representative tissue included in the TMAs. Associations were analysed using the Spearman test (continuous variables) or the Pearson chi-square test (categorical variables). P values are shown, grey boxes indicating significant associations (p15,000/mm3). LYMPH, lymphocytopenia (lymphocyte count (DOC)