Supplementary Table S2: Sig3 scores and FGA values in LMS tumor samples. Sig3+ samples are predicted with a classifier trained in WGS LMS data. FGA values are calculated on CNVkit-based copy number pr

Figshare2023-12-15 更新30

p38-MK2 regulate RNA metabolism after UV light-induced DNA damage

DNA损伤修复

转录调控

Ultraviolet (UV) light induces the formation of bulky UV photoproducts in the genome that interfere with DNA replication and transcription. It is well-established how human cells repair UV light-induc

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Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair

DNA损伤修复

抗癌药物设计

Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that

NIAID Data Ecosystem40

3-methyladenine dna-glycosylase from Archaeoglobus fulgidus

蛋白质结构解析

DNA损伤修复

3-methyladenine dna-glycosylase from Archaeoglobus fulgidus Descriptor: 3-METHYLADENINE DNA-GLYCOSYLASE, GLYCEROL, SODIUM ION Authors: Leiros, I, Nabong, M.P, Grosvik, K, Ringvoll, J, Haugland, G.T, U

Protein Data Bank Japan2023-12-13 更新20

DNA polymerase beta reactant complex with a templating cytosine and incoming 8-oxodGTP, 40 s

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