The chromatin-bound proteome of the human malaria parasite, Plasmodium falciparum

P. falciparum chromatin is highly structured at the three-dimensional (3D) level, and this structure provides an epigenetic mechanism for gene expression regulation. To investigate how parasite nuclear architecture is being maintained and regulated, we undertook complementary computational and experimental approaches to identify and characterize chromatin-associated proteins (CAPs) in P. falciparum. Analysis of chromatin-associated proteins in Plasmodium falciparum during intraerythrocytic stages. In addition, SMC3 occupancy was explored and used to validate the findings from the Chromatin Enrichment for Proteomics (ChEP) methodology in P. falciparum.