The influence of changing the amplitude or duration of one segment of the full-sine waveform depends on current orientation.

(a)Pulse segment amplitude is referenced relative to the unaltered full-sine pulses (i.e. 100%/100% relative amplitude).(b)RMT data were normalized to the unaltered reference pulses for statistical analysis because RMT was significantly different between AP-PA and PA-AP oriented full-sine pulses (cf. Figs. 5 and 6).(c)Current direction refers to induced current in M1-HAND.(d)P-values refer to results of post-hoc Student’s paired t tests between current orientations of the pulse (AP-PA vs. PA-AP).(e)In experiment 3b, duration of a given half-segment was shortened or prolonged, resulting in total pulse durations of 140 or 180 µs, respectively.The influence of changing the amplitude or duration of one segment of the full-sine waveform depends on current orientation.