SESN1 alleviates autoimmunity by potentiating STING autophagic degradation

STING, the pivotal adaptor protein of CGAS-STING signaling, is critical for type I IFN production of innate immunity. However, excessive or prolonged activation of STING is associated with autoinflammatory and autoimmune diseases. Thus, preventing STING from over-activation is important to maintain immune homeostasis. Here, we reported that SESN1 was essential to prevent the excessive activation of STING-mediated type I IFN signaling through autophagic degradation of STING. The mRNA profile of control or SESN1 knockdown Hela cells that stimulated with HTDNA by deep sequencing.