Molecular mechanisms and inhibition of the Grb7 signalling protein in breast cancer

Metastatic breast cancer is considered incurable, and the identification of new molecular targets is a field of interest. One possible therapeutic target is growth factor receptor bound protein 7 (Grb7). It was demonstrated when an aggressive phenotype is induced in breast cancer cell lines Grb7 expression increases. This thesis further demonstrated that the function of inhibitors targeting Grb7 could be restored through the addition and/or removal of amino acids. Finally, it was illustrated that Grb7 inhibition in combination with a chemotherapy, called doxorubicin, did not enhance breast cancer sensitivity to this anti-cancer agent. Other anti-cancer agents should be explored in combination with Grb7 inhibition.