Crystal structure of PDC-3 Y221H beta-lactamase in complex with the boronic acid inhibitor LP-06

Crystal structure of PDC-3 Y221H beta-lactamase in complex with the boronic acid inhibitor LP-06 Descriptor: Beta-lactamase, IMIDAZOLE, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE Authors: Kumar, V, van den Akker, F. Deposit date: 2023-04-07 Release date: 2023-08-16 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Natural protein engineering in the Omega-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas -derived cephalosporinase. Antimicrob.Agents Chemother., 67, 2023