Time course analysis of outer medulla-specific gene expression profiles in the kidneys of Sprague-Dawley rats in a repeated dose study of 2-amino-4-nitrophenol.

In the present study, we performed a general toxicity test and a genome-wide gene expression analysis of rat kidney to identify the mechanisms of 2-amino-4-nitrophenol (ANP) -induced chronic renal failure.本研究中，我们针对大鼠肾脏开展了常规毒性试验与全基因组基因表达分析，以明确2-氨基-4-硝基苯酚（2-amino-4-nitrophenol，ANP）诱导的慢性肾衰竭的作用机制。