Lewis Lung Carcinoma (LLC) cells in the lung model express lung-specific genes compared to subcutaneous engraftment cells.

We revealed that tumor cells in the bleomycin-injured lungs (BLM lungs) are differently influenced by their unique lung fibrogenic microenvironment compared to those in subcutaneous tumor models in vivo or in 2-dimensional monolayer culture in vitro. The gene expression profiles of LLC cells grown in 2-dimensional monolayer culture, in subcutaneous tumors, and in BLM lungs were analyzed (n=3/group).