Expression data from Saccharomyces cerevisiae strains expressing human RECQL5 helicase

We expressed human RECQL5 in the model organism Sacharomyces cerevisiae. We found that RECQL5 overexpression in yeast leads to cell growth inhibition and increased genotoxic sensitivity. We carried-out transcriptome analysis of yeast strains overexpressing human RECQL5 helicase to explore its impact on gene expression. S. cerevisiae strains transformed with a plasmid carrying a tetp-RECQL5 construct were grown in selective minimal medium. Total RNA was isolated from exponential cultures and hybridized on Affymetrix microarrays.