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Transcriptomics analysis of neurogenesis by striatal astrocytes upon Rbpj-K deletion

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NIAID Data Ecosystem2026-03-11 收录
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We achieved local recombination of striatal astrocytes and silenced Notch signalling activity through Rbpj-K depletion. Recombined astrocytes and neural progenitors generated from the striaral glia were FAC sorted and their molecular profile investigated in a scRNAseq experiment performed 5 wpi. Overall design: Astrocytes and their neurogenic progeny isolated from striata of mice homozygous for the floxed Rbpj gene and subjected to local injection of AAV-Gfap-Cre

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2020-08-25
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