Ldb1 mediates trans enhancement in mammals
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
The monoallelic expression of olfactory receptor (OR) genes is governed by a large number of intergenic enhancer elements that are located in intergenic regions of OR gene clusters. In mature olfactory sensory neurons (OSNs), multiple OR enhancers colocalize in an interchromosomal enhancer hub together with the active OR allele. Here we show that in OSNs OR enhancers are bound by Ldb1, but not general purpose mediators of nuclear architecture (CTCF or the cohesin complex subunit Rad21). Conditional deletion of Ldb1 in OSNs results in the dissolution of long range and interchromosomal contacts between OR Enhancers and in pervasive reductions in OR gene expression.
提供机构：
Columbia University Medical Center
创建时间：
2022-02-20
