Gut microbiome and plasma metabolome alterations in myopic mice

Myopia is one of the most common eye diseases leading to blurred distance vision.Although gut microbiota bacteria are associated with various inflammatory diseases,little is known about its role in myopia. In our study, we compared the gut microbiota composition and plasma metabolic phenotype in myopic mice model and controls. We illustrated that myopia shaped the composition of the gut microbiome, and thedysbiosis and disorder of its metabolites may contribute to the progression of myopia. Our study provides new insights into the possible role of the gut microbiota in myopia and reinforces the potential feasibility of microbiome-based therapies in myopia.