Malignant Peripheral Nerve Sheath Tumors are Comprised of Two Epigenetic Subgroups with Distinct Molecular Landscapes, Outcomes and Therapeutic Targets: snRNA Seq Samples

We focused on studying the methylation signature of the spectrum of PNSTs to develop a methylome-based classification of these common tumors. We studied the genome-wide DNA methylation patterns using the Illumina MethylationEPIC array and classified the samples into 5 subgroups. Gene Expression comparing the subgroups were performed using single nuclear RNA Seq Overall design: Single nuclear RNA profiling analysis for different methylation subgroups of PNSTs.