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Facile Synthesis of Naphthoquinone Spiroketals by Diastereoselective Oxidative [3 + 2] Cycloaddition

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NIAID Data Ecosystem2026-03-06 收录
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https://figshare.com/articles/dataset/Facile_Synthesis_of_Naphthoquinone_Spiroketals_by_Diastereoselective_Oxidative_3_2_Cycloaddition/2967955
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资源简介:
A highly selective oxidative [3 + 2] cycloaddition of chiral enol ethers and hydroxynaphthoquinone is described. This convergent strategy is amenable to an enantioselective synthesis of β-rubromycin and related naphthoquinone spiroketals. Several compounds were found to inhibit DNA-polymerase and telomerase in a manner resembling α-rubromycin and β-rubromycin.
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2016-06-03
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