Dinitro-5,5-Dimethylhydantoin: An Arene Nitration Reagent

The development of a new N-nitro type
compound,
dinitro-5,5-dimethylhydantoin (DNDMH), has been reported as an arene
nitration reagent. The exploration demonstrated that arene nitration
with DNDMH exhibited good tolerance with diverse functional groups.
It is notable that, among the two N-nitro units of
DNDMH, only the N-nitro unit on N1 was delivered
to the nitroarene products. The N-nitro type compound
with a single N-nitro unit on N2 cannot promote the
arene nitration.