DM-tRNA-seq of mock and MHV68-infected mouse MC57G fibroblasts
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https://www.ncbi.nlm.nih.gov/sra/SRP238268
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资源简介：
We applied a tRNA-specific sequencing pipeline to analyze tRNA expression during infection of MC57G fibroblasts with the gammaherpesvirus MHV68. We find that expression of 14% of tRNA genes is significantly upregulated during infection. By mapping reads to either premature tRNA (pre-tRNA) or mature tRNA sequences, we find that increased expression of tRNA genes is manifested at the level of the pre-tRNA only, indicating a homeostatic mechanism to maintain the size and composition of mature tRNA pools. Overall design: 4 replicates of DM-tRNA-seq libraries prepared from mock vs MHV68-infected cells
创建时间：
2021-01-12
