Identification of HLA class II-restricted determinants of Mycobacterium tuberculosis-derived proteins by using HLA-transgenic, class II-deficient mice.
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The peptide was derived from the sequence of the M. tuberculosis heat shock protein (hsp) 65. Lymph node cells taken from mice immunized with peptide 1-20 were tested for their ability to proliferate in response to BCG, MTB, hsp65 protein and the hsp65 peptide p1-20. BCG-specific proliferation was observed. MAbs directed against CD4 and DR molecules inhibited T cell proliferation.
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IEDB创建时间：
1998-01-01
