<i>Supporting data for “IDO as Immunosuppressive Biomarker in Non-small Cell Lung Cancer: From Bedside to Benchside and Back”</i>

These supporting data underpin the study titled “IDO as Immunosuppressive Biomarker in Non-small Cell Lung Cancer: From Bedside to Benchside and Back.” They comprise: PBMC single-cell RNA-seq: Compressed barcodes, feature lists, and expression matrices for peripheral blood mononuclear cells, enabling high-resolution profiling of the systemic tumor immune environment.Human flow cytometry (FCS files): Peripheral blood immune‐phenotyping data from NSCLC patients, used to quantify lymphocyte subsets and checkpoint marker expression.Clinical cohort (n = 560): De-identified records of NSCLC patients treated with PD-1/PD-L1 inhibitors, annotated with demographics, comorbidity scores, treatment timelines (ICI, chemotherapy, NSAIDs vs. acetaminophen), and survival outcomes.Murine flow cytometry (FCS files): Peripheral blood immune‐phenotyping data from lung tumor-bearing mice treated with ICI and analgesics support preclinical validation of clinical findings.Together, these multimodal datasets facilitate identification and validation of IDO-associated mechanisms and biomarkers that drive immune suppression and therapeutic resistance in NSCLC.