Simulation condition-dependent model constants.^a

aDetails of the determination of these constants are described in the Materials and Methods section. The subscript “0” indicates steady state for unirradiated cells (0 Gy) or initial concentrations for irradiated cells (10 Gy). Values for these constants were determined for three types of tumor cells: C3 knockout (KO) MEF cells, wild type MEF cells, and wild type 4T1 cells without (0) or with (10) 10-Gy radiation.