ICC and p-values calculated from response data obtained with various registration strategies and A50.

aStatistically significant difference (PAbbreviations: SUV, standardized uptake value; MATV, metabolically active tumour volume; TLG, total lesion glycosysis; AUC, area under a cumulative SUV-volume histogram curve; A50, 3 dimensional (semi-)automatic isocontour method at 50% of the maximum pixel value that corrects for local background; PET, positron emission tomography; CT, computed tomography; ICC, intraclass correlation coefficient; CI, confidence interval; VOI, volume of interest.