Crystal structure of NALP3 PYD Descriptor: NACHT, LRR and PYD domains-containing protein 3 Authors: Park, H.H, Bae, J.Y. Deposit date: 2011-01-21 Release date: 2011-08-31 Last modified: 2024-10-30 Met
3D NMR solution structure of NLRP3 PYD Descriptor: NACHT, LRR and PYD domains-containing protein 3 Authors: de Alba, E, Oroz, J. Deposit date: 2016-01-07 Release date: 2016-07-27 Last modified: 2024-0
Inflammasome complexes form upon interaction of Nod Like Receptor (NLR) proteins with pathogen associated molecular patterns (PAPMS) inside the cytosol. Stimulation of a subset of inflammasome recepto
Gasdermin-D (GSDMD) is cleaved by caspase-1/4/11 in response to canonical and non-canonical inflammasome activation. Upon cleavage, GSDMD oligomerizes and forms membrane pores, resulting in IL-1β sec
Inflammasome activation permits processing of interleukins (IL)-1β and 18 and elicits cell death (pyroptosis). Whether these responses are independently licensed or are “hard-wired” consequences of ca
