Dietary intake of a-ketoglutarate ameliorates a-synuclein pathology in a Parkinson's disease mouse model

In order to investigate the effect of Alpha-Ketoglutarate (AKG) on p-a-synuclein in substantia nigra of Parkinson's disease (PD) model mice (C57BL/6), we profiled substantia nigra from wild-type (WT), AAV-a-synuclein (a-Syn), AKG and a-Syn-AKG in male mice by RNA sequencing (RNA-seq). Overall design: We then performed gene expression profiling analysis using data obtained from RNA-seq of wild-type (WT), AAV-a-synuclein (a-Syn), AKG and a-Syn-AKG mice.