Translational control of breast cancer plasticity

Plasticity of neoplasia, whereby cancer cells attain stem-cell-like properties, is required for disease progression and represents a major therapeutic challenge. Hypoxia induces breast cancer cell plasticity and stem-cell-like phenotypes. Although this process is poorly understood, reports demonstrate that hypoxia induces the expression of stemness-factors including NANOG, SNAIL and NODAL. Moreover, both stem-cell-like phenotypes and elevated expression of stemness-factors have been linked to metastatic spread and chemoresistance. With the use of high through-put sequencing, we characterized the gene expression profiles of T47D breast cancer cells under normoxic and hypoxic conditions. Transcriptomic profiles of T47D breast cancer cells treated with hypoxia with normoixa controls were generated via high throughput sequencing. Three replicates were collected.